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22 studies found for:    DPYD

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Rank Status Study
1 Active, not recruiting Association of Dihydropyrimidine Dehydrogenase (DPYD) Variants With Toxicity Related to Capecitabine
Condition: Breast Cancer
Intervention: Procedure: Phlebotomy
2 Unknown † Pharmacogenomic and Pharmacokinetic Safety and Cost-saving Analysis in Patients Treated With Fluoropyrimidines
Condition: Neoplasms
Intervention: Drug: Capecitabine, 5-fluorouracil
3 Not yet recruiting Pharmacology-driven Dosing of Fluoropyrimidines in Cancer Patients
Condition: Colorectal Cancer
Interventions: Other: 5FU and capecitabine (Xeloda®) dosing based on DPYD genotype;   Other: Therapeutic drug monitoring of 5FU
4 Recruiting Pre-therapeutic Identification of Dihydropyrimidine Dehydrogenase Gene (DPD) Deficiency for Predicting Toxicity to Fluoropyrimidines
Conditions: Colorectal Cancer;   Intravenous 5 Fluorouracile
Intervention: Genetic: Blood sample for phenotypic and pharmacogenetic analysis.
5 Recruiting Study of DPD for Predicting Efficacy and Safety to S-1 Plus Oxaliplatin in Gastrointestinal Cancer
Condition: Gastrointestinal Cancer
Intervention: Drug: S-1 plus oxaliplatin
6 Completed A Study of ADH300004 in Surgically Resected Primary or Metastatic Colorectal Cancer and Liver Biopsy, or Planned Hepatic Resection
Condition: Neoplasms
Intervention: Drug: ADH300004
7 Unknown † Predicting Response to Capecitabine in Women With Metastatic Breast Cancer
Condition: Breast Cancer
Interventions: Drug: capecitabine;   Other: laboratory biomarker analysis;   Other: pharmacological study
8 Completed Eniluracil and Surgery in Treating Patients With Primary or Metastatic Colorectal Cancer
Condition: Colorectal Cancer
Interventions: Drug: eniluracil;   Procedure: conventional surgery
9 Completed A Phase 1, Open-Label, Randomized, Cross-Over, Pharmacokinetic Study Evaluating the Effect of S-1 on Advanced Solid Tumors
Condition: Tumors
Interventions: Drug: S-1;   Drug: FT
10 Completed A Phase I Trial of 5-Fluorouracil Given With 776C85 (GW776) and Low-Dose Leucovorin in Adult Patients With Solid Tumors
Conditions: Lymphoma;   Neoplasms
Interventions: Drug: 5-Fluorouracil;   Drug: Ethynyluracil;   Drug: Leucovorin
11 Active, not recruiting Adjuvant Hepatic Arterial Infusion and Combination Chemotherapy in Treating Patients With Resectable Hepatic Metastases From Colorectal Cancer
Conditions: Colorectal Cancer;   Metastatic Cancer
Interventions: Drug: FOLFOX regimen;   Drug: dexamethasone;   Drug: floxuridine;   Drug: fluorouracil;   Drug: leucovorin calcium;   Drug: oxaliplatin;   Procedure: adjuvant therapy;   Procedure: conventional surgery
12 Recruiting Study of S1 Efficacy and Toxicity as Second-line Treatment on Inoperable or Advanced Gastric Cancers
Condition: Gastric Cancer
Intervention:
13 Recruiting Study of S1 as Second Line Treatment on Advanced Pancreatic Cancers
Condition: Pancreatic Cancer
Interventions: Drug: S1;   Drug: S1 plus LV ( Leucovorin )
14 Suspended A Study of 5 Fluorouracil and the Anti-Tumor Activity of ADH300004 and 5 Fluorouracil in Subjects With Incurable Solid Tumors
Condition: Neoplasms
Intervention: Drug: ADH300004
15 Terminated A Study of ADH300004 and 5-Fluorouracil in Locally Advanced, Recurrent, or Metastatic Hepatocellular Carcinoma
Condition: Hepatocellular Carcinoma
Intervention: Drug: ADH300004
16 Unknown † Pharmacokinetic and Pharmacodynamic Study of S-1 in Patients With Digestive Organ Cancer
Conditions: Gastric Cancer;   Esophageal Cancer;   Pancreatic Cancer;   Colon Cancer
Intervention: Drug: S-1
17 Completed Capecitabine and Docetaxel in Treating Patients With Metastatic Prostate Cancer
Condition: Prostate Cancer
Interventions: Drug: capecitabine;   Drug: docetaxel
18 Completed Safety Study of a New Schedule of Capecitabine and Docetaxel to Treat Cancers
Condition: Metastatic Breast Cancer
Interventions: Drug: Capecitabine;   Drug: Docetaxel
19 Completed Capecitabine and Oxaliplatin in Treating Patients With Metastatic Breast Cancer
Condition: Metastatic Breast Cancer
Interventions: Drug: Capecitabine;   Drug: Oxaliplatin
20 Terminated Gemcitabine and S-1 for Locally Advanced Unresectable or Metastatic Pancreatic Cancer
Condition: Pancreatic Cancer
Interventions: Drug: S-1;   Drug: gemcitabine hydrochloride
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† Indicates status has not been verified in more than two years