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34 studies found for:    DNMT1
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Rank Status Study
1 Completed
Has Results
Low-dose Temozolomide for 2 Weeks on Brain Tumor Enzyme in Patients With Gliomas (P04602 AM1) (Completed)
Condition: Glioma
Intervention: Drug: temozolomide
2 Unknown  Combination Chemotherapy Plus Gene Therapy in Treating Patients With CNS Tumors
Conditions: Bone Marrow Suppression;   Brain and Central Nervous System Tumors;   Drug/Agent Toxicity by Tissue/Organ
Interventions: Procedure: filgrastim;   Biological: gene therapy;   Drug: lomustine;   Drug: procarbazine hydrochloride;   Drug: vincristine sulfate;   Procedure: in vitro-treated peripheral blood stem cell transplantation
3 Unknown  Varenicline for Cognitive Deficits and Cigarette Smoking in Schizophrenia - Efficacy and Predictors
Conditions: Schizophrenia;   Cigarette Smoking
Interventions: Drug: Varenicline;   Drug: Placebo for varenicline
4 Completed KRAS Wild-type Metastatic Colorectal Cancer Trial
Condition: Colorectal Cancer
Interventions: Drug: Dacogen™ (decitabine);   Drug: Vectibix® (panitumumab)
5 Terminated
Has Results
Azacitidine and Lintuzumab in Treating Patients With Previously Untreated Myelodysplastic Syndromes
Conditions: Leukemia;   Myelodysplastic Syndromes
Interventions: Biological: lintuzumab;   Drug: 5-azacytidine
6 Completed
Has Results
Standard Temodal (Temozolomide) Regimen Versus Standard Regimen Plus Early Postsurgery Temodal for Newly Diagnosed Glioblastoma Multiforme (Study P05572)
Condition: Glioblastoma
Interventions: Drug: Temozolomide;   Radiation: Radiotherapy
7 Completed
Has Results
Differentiation Therapy With Decitabine in Treating Patients With Myelodysplastic Syndrome
Conditions: Chronic Myelomonocytic Leukemia;   de Novo Myelodysplastic Syndromes;   Myelodysplastic Syndromes;   Refractory Anemia;   Refractory Anemia With Excess Blasts;   Refractory Anemia With Ringed Sideroblasts;   Refractory Cytopenia With Multilineage Dysplasia;   Thrombocytopenia
Interventions: Other: flow cytometry;   Other: DNA methylation analysis;   Other: cytogenetic analysis;   Drug: decitabine;   Genetic: microarray analysis;   Genetic: gene expression analysis;   Other: pharmacological study;   Genetic: polymorphism analysis
8 Completed
Has Results
Decitabine in Treating Patients With Metastatic Papillary Thyroid Cancer or Follicular Thyroid Cancer Unresponsive to Iodine I 131
Conditions: Recurrent Thyroid Cancer;   Stage IVA Follicular Thyroid Cancer;   Stage IVA Papillary Thyroid Cancer;   Stage IVB Follicular Thyroid Cancer;   Stage IVB Papillary Thyroid Cancer;   Stage IVC Follicular Thyroid Cancer;   Stage IVC Papillary Thyroid Cancer
Interventions: Drug: Decitabine;   Radiation: Iodine I 131;   Biological: Recombinant thyrotropin alfa;   Radiation: Fludeoxyglucose F 18;   Procedure: Positron emission tomography
9 Completed Decitabine With or Without Valproic Acid in Treating Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma
Conditions: Recurrent Adult Burkitt Lymphoma;   Recurrent Adult Diffuse Large Cell Lymphoma;   Recurrent Mantle Cell Lymphoma
Interventions: Drug: decitabine;   Drug: valproic acid;   Other: pharmacological study;   Other: laboratory biomarker analysis
10 Terminated
Has Results
Phase 2 Study of Temozolomide in Pre-Selected Advanced Aerodigestive Tract Cancers (Study P04273AM2)(TERMINATED)
Conditions: Colorectal Neoplasm;   Head and Neck Neoplasm;   Carcinoma, Non-Small-Cell Lung;   Esophageal Neoplasm
Intervention: Drug: Temozolomide
11 Recruiting A Phase 1 Study of CC-486 as a Single Agent and in Combination With Carboplatin or ABI-007 in Subjects With Relapsed or Refractory Solid Tumors
Conditions: Urinary Bladder Neoplasms;   Carcinoma, Transitional Cell;   Ovarian Neoplasms;   Fallopian Tube Neoplasms;   Peritoneal Neoplasms;   Carcinoma, Non-Small-Cell Lung;   Carcinoma, Pancreatic Ductal;   Tumor Virus Infections
Interventions: Drug: CC-486 plus Carboplatin;   Drug: CC-486 plus ABI-007;   Drug: CC-486
12 Recruiting Effect of Quercetin on Green Tea Polyphenol Uptake in Prostate Tissue From Patients With Prostate Cancer Undergoing Surgery
Conditions: Adenocarcinoma of the Prostate;   Recurrent Prostate Cancer;   Stage I Prostate Cancer;   Stage IIA Prostate Cancer;   Stage IIB Prostate Cancer;   Stage III Prostate Cancer;   Stage IV Prostate Cancer
Interventions: Dietary Supplement: green tea extract;   Drug: quercetin;   Other: placebo;   Procedure: therapeutic conventional surgery;   Other: laboratory biomarker analysis
13 Terminated Phase 2 Study of Azacitidine (Vidaza) vs MGCD0103 vs Combination in Elderly Subjects With Newly Diagnosed Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS)
Conditions: Acute Myeloid Leukemia (AML);   Myelodysplastic Syndrome (MDS)
Interventions: Drug: Azacitidine;   Drug: MGCD0103
14 Completed Varenicline Effects In Schizophrenic Smokers
Conditions: Schizophrenia;   Tobocco Use Disorder;   Nicotine Dependance
Intervention: Drug: Varenicline
15 Completed
Has Results
Study of Recurrent Prostate Cancer With Rising Prostate Specific Antigen (PSA)
Condition: Prostate Cancer
Intervention: Drug: Disulfiram
16 Withdrawn QOL-Stereotactic RadioSurgery, Temozolomide + Erlotinib-Rx of 1-3 Brain Metastases in NSCLC
Conditions: Lung Cancer;   Metastatic Cancer
Interventions: Drug: erlotinib hydrochloride;   Drug: temozolomide;   Radiation: stereotactic radiosurgery
17 Withdrawn Efficacy and Safety of 5-day Dosing of ON 01910.Na in Intermediate-1,-2, or High Risk Myelodysplastic Syndrome (MDS)
Condition: Myelodysplastic Syndrome
Intervention: Drug: ON 01910.Na Concentrate
18 Unknown  Decitabine and Plerixafor in Elderly Acute Myeloid Leukemia (AML)
Condition: Acute Myeloid Leukemia
Interventions: Drug: plerixafor;   Drug: decitabine
19 Completed Temozolomide and Everolimus in Treating Patients With Stage IV Melanoma That Cannot be Removed by Surgery
Condition: Melanoma (Skin)
Interventions: Drug: everolimus;   Drug: temozolomide;   Genetic: reverse transcriptase-polymerase chain reaction;   Other: flow cytometry;   Other: immunohistochemistry staining method;   Other: immunologic technique
20 Recruiting Temozolomide 12 Cycles Versus 6 Cycles of Standard First-line Treatment in Patients With Glioblastoma.
Condition: Glioblastoma
Intervention: Drug: Temozolomide

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Indicates status has not been verified in more than two years