Now Available for Public Comment: Notice of Proposed Rulemaking (NPRM) for FDAAA 801 and NIH Draft Reporting Policy for NIH-Funded Trials
68 studies found for:    CXCR4
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Rank Status Study
1 Active, not recruiting Anti-CXCR4 (BMS-936564) Alone and in Combination With Lenalidomide/Dexamethasone or Bortezomib/Dexamethasone in Relapsed/Refractory Multiple Myeloma
Condition: Multiple Myeloma
Interventions: Biological: Anti-CXCR4  (BMS-936564);   Biological: Lenalidomide;   Biological: Dexamethasone;   Biological: Bortezomib
2 Recruiting Imaging CXCR4 Expression in Subjects With Cancer Using 64 Cu-Plerixafor
Condition: Cancer
Intervention: Drug: 64-Cu-plerixafor
3 Unknown  Correlation of CXCR4 Expression in Premature Infants With a Diagnosis of Autism at 24 Months
Conditions: Autism Spectrum Disorder;   Prematurity
Intervention:
4 Completed Safety Study of a Chemokine Receptor (CXCR4) Antagonist in Multiple Myeloma Patients
Condition: Multiple Myeloma
Intervention: Drug: BKT140
5 Not yet recruiting Imatinib and BL-8040 (Novel Anti CXCR4 Antagonist) for Improving Molecular Response in Chronic Myelogenous Leukemia
Condition: Chronic Myeloid Leukemia
Intervention: Drug: BL-8040
6 Recruiting CXCR4 Antagonism for Cell Mobilisation and Healing in Acute Myocardial Infarction (CATCH-AMI)
Condition: Large Reperfused ST-Elevation Myocardial Infarction
Interventions: Drug: POL6326;   Drug: Placebo
7 Completed
Has Results
AMD 3100 for Treatment of Myelokathexis
Condition: Neutropenia
Intervention: Drug: AMD3100 or plerixafor
8 Active, not recruiting First in Human Study to Determine the Safety, Tolerability and Preliminary Efficacy of an Anti-CXCR4 Antibody in Subjects With Acute Myelogenous Leukemia and Selected B-cell Cancers
Conditions: Acute Myelogenous Leukemia;   Diffuse Large B-Cell Leukemia;   Chronic Lymphocytic Leukemia;   Follicular Lymphoma
Intervention: Drug: BMS-936564 (Anti-CXCR4)
9 Unknown  The Role of SDF-1/CXCR4 in Metastasis of Oral Squamous Cell Carcinoma
Condition: Oral Cancer
Intervention:
10 Unknown  The Role of Stromal Cell-Derived Factor-1 (SDF-1)/CXC Chemokine Receptor 4 (CXCR4) in Metastasis of Laryngeal and Hypopharyngeal Squamous Cell Carcinoma
Conditions: Laryngeal Cancer;   Hypopharyngeal Cancer;   Metastasis
Intervention:
11 Completed Auto-immunity in Lupus Patients After Influenza Vaccine
Condition: Systemic Lupus Erythematosus (SLE)
Intervention: Drug: Vaccine
12 Completed A Trial to Establish the Feasibility of Combining Either the Tyrosine Kinase Inhibitor AC220,CXCR4 Inhibitor Plerixafor or HSP90 Inhibitor Ganetespib With Chemotherapy in Older Patients With Acute Myeloid Leukaemia and High Risk Myelodysplastic Syndrome.
Conditions: Acute Myeloid Leukaemia;   High Risk Myelodysplastic Syndrome
Interventions: Drug: Plerixafor;   Drug: AC220;   Drug: Ganetespib
13 Recruiting Plerixafor Versus G-CSF in the Treatment of People With WHIM Syndrome
Conditions: Myelokathexis;   WHIMS;   Neutropenia;   Warts
Interventions: Drug: Plerixafor;   Drug: G-CSF
14 Unknown  Studies on the Significance of CXCR4-CXCL12 on Leukemic Cells Passing Through"Marrow-Blood Barrier"
Conditions: Acute Myelocytic Leukemia;   Acute Lymphocytic Leukemia
Intervention:
15 Completed Safety and Activity of the Oral HIV Entry Inhibitor AMD11070 in HIV Infected Patients
Condition: HIV Infections
Intervention: Drug: AMD11070
16 Terminated First in Man Study of ALX-0651, a Nanobody Inhibiting CXCR4
Condition: Healthy Volunteers
Interventions: Biological: ALX-0651;   Biological: Placebo
17 Active, not recruiting Chemosensitization With Plerixafor Plus G-CSF in Acute Myeloid Leukemia
Condition: Leukemia, Myeloid, Acute
Interventions: Drug: G-CSF;   Drug: Plerixafor;   Drug: Mitoxantrone;   Drug: Etoposide;   Drug: Cytarabine
18 Recruiting Prognostic Potential of Cell Surface Markers and Pim Kinases in Multiple Myeloma
Condition: Multiple Myeloma
Intervention:
19 Recruiting Prognostic Potential Cell Surface Marker and Pim-kinase in Patients With Hematologic Malignancies or Solid Tumors
Conditions: Solid Tumor;   Ovarian Cancer;   Non-small Cell Lung Cancer;   Chronic Lymphocytic Leukemia;   Burkitt's Lymphoma
Intervention:
20 Completed IV Plerixafor With Mitoxantrone Etoposide and Cytarabine for Acute Myeloid Leukemia (AML)
Condition: Leukemia, Myeloid, Acute
Interventions: Drug: Plerixafor;   Drug: Mitoxantrone;   Drug: Etoposide;   Drug: Cytarabine

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Indicates status has not been verified in more than two years