169 studies found for:    BRCA1
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Rank Status Study
1 Unknown  The Potential for Oral Diindolylmethane (DIM) Supplementation to Increase the Production of the BRCA1 Protein in BRCA1 Mutation Carriers
Condition: Breast Cancer
Intervention: Dietary Supplement: Diindolylmethane (DIM)
2 Active, not recruiting A Qualitative Exploration of the Impact of Positive BRCA1/2 Mutation Status on the Lives of Young Women
Conditions: Breast Cancer;   BRCA1 Gene;   BRCA2 Gene
Intervention:
3 Unknown  Impact of Testing Positive for the BRCA1 or BRCA2 Mutation in Young Women Who Are BRCA1 or BRCA2 Mutation Carriers
Conditions: brca1 Mutation Carrier;   brca2 Mutation Carrier;   Sexuality and Reproductive Issues
Interventions: Behavioral: telephone-based intervention;   Other: questionnaire administration;   Procedure: psychosocial assessment and care
4 Recruiting Letrozole in Preventing Breast Cancer in Postmenopausal Women With a BRCA1 or BRCA2 Mutation
Conditions: brca1 Mutation Carrier;   brca2 Mutation Carrier;   Breast Cancer;   Hereditary Breast/Ovarian Cancer (brca1, brca2)
Intervention: Drug: letrozole
5 Withdrawn Breast Cancer Risk in Women Who Are BRCA1/BRCA2 Mutation Carriers
Conditions: brca1 Mutation Carrier;   brca2 Mutation Carrier;   Breast Cancer
Interventions: Genetic: DNA analysis;   Genetic: mutation analysis;   Genetic: polymorphism analysis;   Other: laboratory biomarker analysis;   Procedure: evaluation of cancer risk factors
6 Unknown  Studying Breast Cancer Risk in Women Who Are BRCA1/BRCA2 Mutation Carriers
Conditions: brca1 Mutation Carrier;   brca2 Mutation Carrier;   Breast Cancer
Interventions: Genetic: DNA analysis;   Genetic: mutation analysis;   Genetic: polymorphism analysis;   Other: laboratory biomarker analysis;   Procedure: evaluation of cancer risk factors
7 Recruiting Standard Genetic Counseling With or Without a Decision Guide in Improving Communication Between Mothers Undergoing BRCA1/2 Testing and Their Minor-Age Children
Conditions: Breast Cancer;   Hereditary Breast/Ovarian Cancer (brca1, brca2)
Interventions: Other: counseling intervention;   Other: educational intervention;   Other: survey administration;   Behavioral: psychosocial assessment and care;   Behavioral: supportive care
8 Completed BRCA1 Haploinsufficiency and Gene Expression
Condition: BRCA1 Mutations
Intervention:
9 Completed Open-Label,Non-Randomized Trial of Cisplatin Chemotherapy in BRCA1-Positive Metastatic Breast Cancer Patients
Conditions: BRCA1 Mutation;   Metastatic Breast Cancer
Intervention: Drug: Cisplatin
10 Recruiting The IMPACT Study - Identification of Men With a Genetic Predisposition to ProstAte Cancer
Condition: Prostate Cancer in BRCA1 and BRCA2 Carriers
Interventions: Behavioral: PSA test;   Procedure: Prostate Biopsy
11 Unknown  Cisplatin-monotherapy in the Treatment of BRCA1 Positive Breast Cancer Patients in Poland
Conditions: BRCA1 Mutation;   Breast Cancer Invasive Nos
Intervention: Drug: Neoadjuvant Cisplatin Chemotherapy
12 Recruiting COsegregation of VARiants in the BRCA1/2 Genes
Conditions: Genes, BRCA1;   Genes, BRCA2;   Ovarian Neoplasms;   Breast Neoplasms
Intervention: Genetic: salivary kit
13 Recruiting Study With Trabectedin in BRCA1 and BRCA2 Mutation Carrier and BRCAness Phenotype Ovarian Cancer
Condition: BRCA1 and BRCA2 Mutation Carrier and BRCAness Phenotype
Intervention: Drug: Trabectedin
14 Active, not recruiting Testing BRCA 1/2 Mutation Using Next Generation Sequencing
Conditions: Breast Neoplasms;   Breast Cancer
Intervention:
15 Not yet recruiting Decision Support Following Genetic Testing for Breast-Ovarian Cancer Susceptibility
Conditions: Breast Cancer;   Ovarian Cancer
Interventions: Behavioral: Enhanced Internet DA;   Behavioral: Internet DA;   Behavioral: Enhanced Print DA;   Behavioral: Print DA;   Behavioral: Inconclusive Results DA
16 Unknown  Validation of a Mouse Model of Pancreatic Carcinogenesis
Condition: Pancreatic Cancer
Intervention:
17 Unknown  Individualized Chemotherapy Based on BRCA1 and RRM1 mRNA for Advanced Non-small Cell Lung Cancer (NSCLC)
Condition: Non-small Cell Lung Cancer
Interventions: Drug: Gemcitabine, Docetaxel, CPT-11,Cisplatin;   Drug: gemcitabine/cisplatin
18 Active, not recruiting Open Label Study to Assess Efficacy and Safety of Olaparib in Confirmed Genetic BRCA1 or BRCA2 Mutation Pats
Conditions: Ovarian;   Breast;   Prostate;   Pancreatic;   Advanced Tumours
Intervention: Drug: olaparib
19 Not yet recruiting BRCA1/2 and Effect of Mifepristone on the Breast
Condition: Women With Mutations in the Breast Cancer Susceptibility Genes BRCA-1 and -2.
Intervention: Drug: Mifepristone
20 Active, not recruiting Veliparib in Treating Patients With Malignant Solid Tumors That Did Not Respond to Previous Therapy
Conditions: BRCA1 Mutation Carrier;   BRCA2 Mutation Carrier;   Estrogen Receptor-negative Breast Cancer;   HER2-negative Breast Cancer;   Hereditary Breast/Ovarian Cancer (BRCA1, BRCA2);   Male Breast Cancer;   Progesterone Receptor-negative Breast Cancer;   Recurrent Breast Cancer;   Recurrent Fallopian Tube Cancer;   Recurrent Ovarian Epithelial Cancer;   Recurrent Pancreatic Cancer;   Recurrent Primary Peritoneal Cavity Cancer;   Recurrent Prostate Cancer;   Triple-negative Breast Cancer;   Unspecified Adult Solid Tumor, Protocol Specific
Interventions: Drug: veliparib;   Other: pharmacological study;   Other: laboratory biomarker analysis

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Indicates status has not been verified in more than two years