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186 studies found for:    "Scleroderma, Systemic"

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Rank Status Study
21 Unknown † Study of Ambrisentan With Antifibrotic Agent Combination Therapy in Diffuse Systemic Sclerosis
Conditions: Systemic Sclerosis;   Scleroderma
Intervention: Drug: Ambrisentan with an anti-fibrotic agent to assess benefit on skin.
22 Completed Safety, Tolerability, and Pharmacokinetics of CAT-192 (Human Anti-TGF-Beta1 Monoclonal Antibody) in Patients With Early Stage Diffuse Systemic Sclerosis
Conditions: Systemic Sclerosis;   Scleroderma
Intervention: Drug: Human Anti-Transforming Growth Factor Beta-1 Monoclonal Antibody
23 Terminated Thalidomide for Decreasing Collagen Biosynthesis in People With Progressive Systemic Sclerosis
Condition: Scleroderma, Systemic
Interventions: Drug: Thalidomide;   Drug: Placebo thalidomide
24 Recruiting A Clinical Trial of Ambrisentan and Tadalafil in Pulmonary Arterial Hypertension Associated With Systemic Sclerosis
Conditions: Pulmonary Arterial Hypertension;   Systemic Sclerosis;   Scleroderma Spectrum of Diseases;   Connective Tissue Disease;   Pulmonary Hypertension
Interventions: Drug: Tadalafil monotherapy;   Drug: Ambrisentan monotherapy;   Drug: tadalafil and ambrisentan
25 Completed Efficacy and Safety Study of GB-0998 for Treatment of Systemic Sclerosis
Condition: Scleroderma, Systemic
Intervention: Drug: High-dose intravenous immunoglobulin (Venoglobulin-IH)
26 Completed Efficacy and Safety of Oral Bosentan in Pulmonary Fibrosis Associated With Scleroderma
Conditions: Pulmonary Fibrosis;   Scleroderma, Systemic
Intervention: Drug: Bosentan
27 Active, not recruiting Comparison of Therapeutic Regimens for Scleroderma Interstitial Lung Disease (The Scleroderma Lung Study II)
Conditions: Scleroderma;   Interstitial Lung Disease
Interventions: Drug: Mycophenolate mofetil;   Drug: Cyclophosphamide;   Drug: Placebo
28 Completed A Study to Evaluate the Efficacy of an Oral Medication in the Treatment and Prevention of Digital Ulcers in Patients With Systemic Sclerosis (Scleroderma).
Conditions: n Ulcer;   Scleroderma, Systemic
Intervention: Drug: Ambrisentan
29 Completed Study of Silicone-Associated Connective Tissue Diseases
Conditions: Autoimmune Diseases;   Connective Tissue Diseases;   Scleroderma, Circumscribed;   Scleroderma, Systemic
Intervention:
30 Unknown † Effectiveness of UVA1-irradiation in the Treatment of Early Skin Fibrosis in Patients Suffering From Systemic Sclerosis
Conditions: Systemic Scleroderma;   Systemic Sclerosis
Interventions: Radiation: UVA1;   Other: UVA1
31 Completed High Dose Cyclophosphamide for Treatment of Scleroderma
Condition: Scleroderma
Intervention: Drug: High Dose Cyclophosphamide
32 Terminated Treatment of Early Systemic Sclerosis by Bosentan
Condition: Systemic Sclerosis (Scleroderma)
Intervention: Drug: bosentan
33 Completed
Has Results 		Imatinib in Systemic Sclerosis
Condition: Scleroderma, Systemic
Intervention: Drug: Imatinib mesylate
34 Unknown † Genesis of Scleroderma: Role of Environmental Factors in 100 Patients With Scleroderma and 300 Controls
Condition: Scleroderma
Intervention:
35 Active, not recruiting Scleroderma: Cyclophosphamide or Transplantation (SCOT)
Conditions: Scleroderma, Systemic;   Sclerosis;   Autoimmune Disease
Interventions: Procedure: Autologous stem cell transplantation;   Drug: Cyclophosphamide;   Drug: Antithymocyte globulin, equine;   Drug: Methylprednisolone;   Drug: Growth colony stimulating factor (G-CSF);   Radiation: Total body irradiation (TBI)
36 Recruiting SCOT Scleroderma Treatment Alternative Registry (STAR Registry)
Conditions: Scleroderma, Systemic;   Sclerosis
Intervention: Behavioral: Telephone Call
37 Unknown † Neuropsychiatric Scleroderma Study: Systematic Evaluation of Neuropsychiatric Involvement in Systemic Sclerosis
Condition: Systemic Sclerosis
Intervention: Other: Magnetic resonance Imaging
38 Recruiting Autologous Stem Cell Systemic Sclerosis Immune Suppression Trial
Condition: Scleroderma
Interventions: Procedure: Rituximab sandwich regiment followed by SCT;   Procedure: cyclophosphamide regiment followed by SCT
39 Recruiting Laser Speckle Contrast Imaging for Cutaneous Microvascular Dysfunction Detection in Systemic Sclerosis.
Conditions: Raynaud Disease;   Scleroderma, Systemic
Interventions: Procedure: laser speckle contrast imaging;   Procedure: Cooling
40 Unknown † Stress Echocardiography in the Detection of Pulmonary Arterial Hypertension in Systemic Sclerosis Patients
Conditions: Scleroderma, Systemic;   Hypertension, Pulmonary
Intervention:
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† Indicates status has not been verified in more than two years