470 studies found for:    "Neurotoxicity syndromes"
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Rank Status Study
1 Terminated A Pilot Study of Dextromethorphan for the Prevention and Treatment of Methotrexate Neurotoxicity
Condition: Neurotoxicity Syndromes
Intervention: Drug: Dextromethorphan
2 Active, not recruiting Calcium Gluconate and Magnesium Sulfate in Preventing Neurotoxicity in Patients With Colon Cancer or Rectal Cancer Receiving Oxaliplatin-Based Combination Chemotherapy
Conditions: Chemotherapeutic Agent Toxicity;   Colorectal Cancer;   Neuropathy;   Neurotoxicity
Interventions: Drug: calcium gluconate;   Drug: magnesium sulfate;   Other: placebo
3 Unknown  Biomarkers in Predicting Neurotoxicity in Patients With Colorectal Cancer Receiving Oxaliplatin
Conditions: Chemotherapeutic Agent Toxicity;   Colorectal Cancer;   Neurotoxicity
Interventions: Drug: FOLFOX regimen;   Drug: fluorouracil;   Drug: leucovorin calcium;   Drug: oxaliplatin;   Genetic: gene expression analysis;   Genetic: protein expression analysis;   Genetic: proteomic profiling;   Other: laboratory biomarker analysis;   Other: pharmacogenomic studies
4 Completed
Has Results
Calcium Gluconate and Magnesium Sulfate in Preventing Neurotoxicity Caused By Oxaliplatin in Patients Receiving Combination Chemotherapy for Stage II, Stage III, or Stage IV Colorectal Cancer That Has Been Completely Removed By Surgery
Conditions: Colorectal Cancer;   Neurotoxicity
Interventions: Drug: calcium gluconate;   Drug: magnesium sulfate;   Other: placebo
5 Completed Protective Effect of Mangafodipir Against Oxaliplatin Neurotoxicity
Conditions: Neurotoxic Disorders;   Cancer
Intervention: Drug: Mangafodipir
6 Recruiting Study to Assess Prevention of Oxaliplatin-induced Neurotoxicity Through Vitamin D Pathway
Condition: Neurotoxicity
Intervention: Drug: Vitamin D3
7 Unknown  Duloxetine in Treating Peripheral Neuropathy Caused by Chemotherapy in Patients With Cancer
Conditions: Neurotoxicity Syndromes;   Pain;   Peripheral Neuropathy;   Unspecified Adult Solid Tumor, Protocol Specific
Interventions: Drug: duloxetine hydrochloride;   Other: placebo
8 Terminated Amifostine in Treating Women With Ovarian, Peritoneal, Cervical, Fallopian Tube, Uterine, or Endometrial Cancer
Conditions: Cervical Cancer;   Endometrial Cancer;   Fallopian Tube Cancer;   Neurotoxicity;   Ovarian Cancer;   Primary Peritoneal Cavity Cancer;   Sarcoma
Interventions: Drug: amifostine trihydrate;   Drug: cisplatin;   Drug: paclitaxel
9 Withdrawn Scopolamine Treatment for Patients With Organophosphate Poisoning
Condition: Neurotoxicity Syndromes
Intervention: Drug: Placebo
10 Recruiting Heavy Metal Exposure in Predicting Peripheral Neuropathy in Patients With Stage I-III Breast Cancer Undergoing Chemotherapy
Conditions: Male Breast Cancer;   Neurotoxicity;   Peripheral Neuropathy;   Stage IA Breast Cancer;   Stage IB Breast Cancer;   Stage II Breast Cancer;   Stage IIIA Breast Cancer;   Stage IIIB Breast Cancer;   Stage IIIC Breast Cancer
Interventions: Other: laboratory biomarker analysis;   Other: questionnaire administration
11 Unknown  Baclofen-Amitriptyline Hydrochloride-Ketamine Gel in Treating Peripheral Neuropathy Caused by Chemotherapy in Patients With Cancer
Conditions: Chronic Myeloproliferative Disorders;   Leukemia;   Lymphoma;   Lymphoproliferative Disorder;   Multiple Myeloma and Plasma Cell Neoplasm;   Myelodysplastic Syndromes;   Myelodysplastic/Myeloproliferative Neoplasms;   Neurotoxicity;   Pain;   Unspecified Adult Solid Tumor, Protocol Specific
Interventions: Drug: baclofen/amitriptyline/ketamine gel;   Other: placebo
12 Completed Brain Function in Children Previously Treated on Clinical Trials POG-9605 and POG-9201
Conditions: Long-term Effects Secondary to Cancer Therapy in Children;   Neurotoxicity
Intervention: Procedure: management of therapy complications
13 Active, not recruiting Effects of Chemotherapy on the Brain in Women With Newly Diagnosed Early-Stage Breast Cancer
Conditions: Breast Cancer;   Chemotherapeutic Agent Toxicity;   Cognitive/Functional Effects;   Fatigue;   Long-term Effects Secondary to Cancer Therapy in Adults;   Neurotoxicity;   Psychosocial Effects of Cancer and Its Treatment
Interventions: Biological: trastuzumab;   Drug: aromatase inhibition therapy;   Drug: carboplatin;   Drug: cyclophosphamide;   Drug: docetaxel;   Drug: doxorubicin hydrochloride;   Other: metabolic assessment;   Other: questionnaire administration;   Other: study of socioeconomic and demographic variables;   Procedure: cognitive assessment;   Procedure: positron emission tomography;   Radiation: fludeoxyglucose F 18
14 Recruiting Modafinil in Treating Children With Memory and Attention Problems Caused by Cancer Treatment for a Brain Tumor
Conditions: Brain and Central Nervous System Tumors;   Cognitive/Functional Effects;   Fatigue;   Neurotoxicity;   Psychosocial Effects of Cancer and Its Treatment
Interventions: Drug: modafinil;   Other: placebo
15 Withdrawn Acetyl-L-Carnitine Hydrochloride in Preventing Peripheral Neuropathy in Patients With Recurrent Ovarian Epithelial Cancer, Primary Peritoneal Cavity Cancer, or Fallopian Tube Cancer Undergoing Chemotherapy
Conditions: Fallopian Tube Cancer;   Fatigue;   Neuropathy;   Neurotoxicity;   Ovarian Cancer;   Pain;   Primary Peritoneal Cavity Cancer
Interventions: Dietary Supplement: acetyl-L-carnitine hydrochloride;   Drug: carboplatin;   Drug: cisplatin;   Drug: paclitaxel;   Other: placebo
16 Terminated Adderall XR Compared With Concerta in Treating Young Cancer Patients With Memory, Attention, and Depression
Conditions: Depression;   Neurotoxicity;   Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: Drug: Adderall-XR®;   Drug: Concerta®
17 Completed Vitamin E in Preventing Peripheral Neuropathy Caused by Chemotherapy in Patients Receiving Chemotherapy for Cancer
Conditions: Neurotoxicity;   Unspecified Adult Solid Tumor, Protocol Specific
Interventions: Dietary Supplement: vitamin E;   Other: placebo
18 Completed Methotrexate, Glucarpidase, and Leucovorin in Treating Patients With Newly Diagnosed Primary Central Nervous System Lymphoma
Conditions: Chemotherapeutic Agent Toxicity;   Lymphoma;   Mucositis;   Neurotoxicity
Interventions: Drug: glucarpidase;   Drug: leucovorin calcium;   Drug: methotrexate;   Other: laboratory biomarker analysis;   Procedure: quality-of-life assessment;   Radiation: radiation therapy
19 Terminated Ph I Study of Lithium During Whole Brain Radiotherapy For Patients With Brain Metastases
Conditions: Brain and Central Nervous System Tumors;   Cognitive/Functional Effects;   Neurotoxicity;   Solid Tumor
Interventions: Drug: lithium carbonate;   Procedure: cognitive assessment;   Procedure: quality-of-life assessment;   Radiation: radiation therapy
20 Unknown  Acute Pain Caused by Paclitaxel in Patients With Cancer
Conditions: Chemotherapeutic Agent Toxicity;   Neurotoxicity;   Pain;   Unspecified Adult Solid Tumor, Protocol Specific
Interventions: Drug: paclitaxel;   Genetic: polymorphism analysis;   Other: laboratory biomarker analysis;   Other: questionnaire administration;   Procedure: assessment of therapy complications

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Indicates status has not been verified in more than two years