31 studies found for:    "Li Fraumeni syndrome"
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"Li Fraumeni syndrome" (31 records)
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Rank Status Study
1 Recruiting Clinical and Genetic Studies of Li-Fraumeni Syndrome
Conditions: Li-Fraumeni Syndrome;   Neoplasms;   Tp53 Mutations
Intervention:
2 Recruiting Magnetic Resonance Imaging Screening in Li Fraumeni Syndrome
Condition: Li-Fraumeni Syndrome
Interventions: Other: Whole body MRI;   Other: Psychological questionnaires
3 Recruiting Role of p53 Gene in Metabolism Regulation in Patients With Li-Fraumeni Syndrome
Condition: Li-Fraumeni Syndrome
Intervention:
4 Recruiting A Pilot Study of Metformin in Patients With a Diagnosis of Li-Fraumeni Syndrome
Condition: Li-Fraumeni Syndrome
Intervention: Drug: Metformin
5 Recruiting LIFSCREEN : Evaluation of Whole Body MRI for Early Detection of Cancers in Subjects With P53 Mutation (Li-Fraumeni Syndrome)
Condition: Li Fraumeni Syndrome
Intervention: Other: whole body MRI
6 Unknown  p53 Gene Therapy for Head and Neck Malignant Tumors in Advanced Stage
Condition: Neoplasms
Interventions: Drug: chemotherapy plus p53;   Drug: chemotherapy;   Radiation: radiotherapy
7 Unknown  rAd-p53 Gene Therapy for Advanced Malignant Thyroid Tumors
Condition: Advanced Malignant Thyroid Tumors
Interventions: Drug: rAd-p53 gene;   Procedure: surgery;   Drug: p53 gene therapy;   Radiation: p53 gene therapy with radioactive iodine
8 Unknown  rAd-p53 Gene Therapy for Advanced Oral and Maxillofacial Malignant Tumors
Condition: Advanced Oral and Maxillofacial Malignant Tumors
Interventions: Drug: p53 gene with surgery;   Procedure: surgery;   Drug: p53 with chemotherapy;   Drug: p53 gene therapy
9 Not yet recruiting Surgery Combined With rAd-p53 Gene in Treatment Advanced Non-small-cell Carcinoma
Condition: Non-small Cell Lung Cancer
Interventions: Drug: Surgery combined with rAd-p53 gene therapy;   Procedure: Surgery
10 Terminated Wild Type p53 Adenovirus for Oral Premalignancies
Condition: Mouth Cancer
Intervention: Genetic: INGN 201
11 Recruiting Study to Determine and Evaluate a Safe and Tolerated Dose of HDM201 in Patients With Selected Advanced Tumors That Are TP53wt
Condition: Advanced Solid and Hematological TP53wt Tumors
Intervention: Drug: HDM201
12 Completed Biomarker (p53 Gene) Analysis and Combination Chemotherapy Followed by Radiation Therapy and Surgery in Treating Women With Large Operable or Locally Advanced or Inflammatory Breast Cancer
Condition: Breast Cancer
Interventions: Biological: filgrastim;   Drug: cyclophosphamide;   Drug: docetaxel;   Drug: epirubicin hydrochloride;   Drug: fluorouracil;   Genetic: microarray analysis;   Other: immunohistochemistry staining method;   Other: laboratory biomarker analysis;   Procedure: biopsy;   Procedure: conventional surgery;   Procedure: neoadjuvant therapy;   Radiation: radiation therapy
13 Active, not recruiting A Study of MK-1775 in Combination With Paclitaxel and Carboplatin Versus Paclitaxel and Carboplatin Alone for Participants With Platinum-Sensitive Ovarian Tumors With the P53 Gene Mutation (MK-1775-004)
Condition: Ovarian Cancer
Interventions: Drug: MK-1775;   Drug: Placebo;   Drug: paclitaxel;   Drug: carboplatin
14 Completed Gene Therapy in Treating Patients With Recurrent Malignant Gliomas
Condition: Brain and Central Nervous System Tumors
Interventions: Biological: Ad5CMV-p53 gene;   Procedure: conventional surgery
15 Unknown  Gene Therapy in Treating Patients With Advanced Recurrent or Persistent Ovarian Cancer or Primary Peritoneal Cancer
Conditions: Ovarian Cancer;   Peritoneal Cavity Cancer
Intervention: Biological: Ad5CMV-p53 gene
16 Unknown  Duct Endoscopy in Assessing Cellular Atypia in the Breast Duct Fluid of Women With a Genetic Risk for Breast Cancer
Condition: Breast Cancer
Interventions: Genetic: cytogenetic analysis;   Genetic: proteomic profiling;   Other: cytology specimen collection procedure;   Other: immunohistochemistry staining method;   Other: laboratory biomarker analysis;   Procedure: breast duct lavage
17 Completed Chemotherapy Followed By Vaccine Therapy in Treating Patients With Extensive-Stage Small Cell Lung Cancer
Condition: Lung Cancer
Interventions: Biological: Autologous dendritic cell-adenovirus p53 vaccine;   Drug: Carboplatin;   Drug: Etoposide
18 Completed Gene Therapy in Preventing Cancer in Patients With Premalignant Carcinoma of the Oral Cavity or Pharynx
Conditions: Lip and Oral Cavity Cancer;   Oropharyngeal Cancer;   Stage 0 Lip and Oral Cavity Cancer;   Stage 0 Oropharyngeal Cancer;   Tongue Cancer
Interventions: Biological: Ad5CMV-p53 gene;   Other: laboratory biomarker analysis
19 Recruiting Tissue Banking Study - Polycythemia Vera or Essential Thrombocythemia (PV & ET) Patients
Conditions: Polycythemia Vera;   Essential Thrombocythemia
Intervention: Procedure: Blood specimen
20 Active, not recruiting To Immunize Patients With Extensive Stage SCLC Combined With Chemo With or Without All Trans Retinoic Acid
Condition: Small Cell Lung Cancer
Interventions: Drug: Paclitaxel;   Biological: Drug: Ad.p53-DC vaccines;   Drug: All -trans Retinoic Acid (ATRA)

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Indicates status has not been verified in more than two years