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129 studies found for:    "AL amyloidosis"

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Rank Status Study
21 Terminated Melphalan and Dexamethasone With or Without Bortezomib in Treating Patients With Previously Untreated Systemic Light-Chain Amyloidosis
Conditions: Light Chain Deposition Disease;   Primary Systemic Amyloidosis
Interventions: Drug: melphalan;   Drug: dexamethasone;   Drug: bortezomib
22 Recruiting A Safety Study of Carfilzomib in Patients With Previously-Treated Systemic Light Chain Amyloidosis
Conditions: Amyloidosis;   Systemic Light-Chain Amyloidosis
Interventions: Drug: Carfilzomib;   Drug: Dexamethasone
23 Active, not recruiting S0115, High-Dose Melphalan and Autologous Peripheral Stem Cell Transplantation in Treating Patients With Multiple Myeloma or Primary Systemic Amyloidosis
Conditions: Multiple Myeloma;   Plasma Cell Myeloma
Interventions: Biological: filgrastim;   Drug: cyclophosphamide;   Drug: dexamethasone;   Drug: melphalan;   Drug: thalidomide;   Procedure: peripheral blood stem cell transplantation
24 Recruiting Phase I, Open Label, Dose Escalation Study of NEOD001 in Subjects With Light Chain (AL) Amyloidosis
Condition: Primary Amyloidosis
Intervention: Drug: NEOD001
25 Completed S9628 Dexamethasone Plus Interferon Alfa in Treating Patients With Primary Systemic Amyloidosis
Condition: Multiple Myeloma
Interventions: Biological: recombinant interferon alfa;   Drug: dexamethasone
26 Completed CC-5013 With or Without Dexamethasone in Treating Patients With Primary Systemic Amyloidosis
Condition: Multiple Myeloma and Plasma Cell Neoplasm
Interventions: Drug: dexamethasone;   Drug: lenalidomide
27 Active, not recruiting Melphalan, Lenalidomide, and Dexamethasone in Treating Patients With Primary Systemic Amyloidosis
Condition: Multiple Myeloma and Plasma Cell Neoplasm
Interventions: Drug: dexamethasone;   Drug: lenalidomide;   Drug: melphalan
28 Active, not recruiting Melphalan, Bortezomib, and Stem Cell Transplant in Treating Patients With Primary Systemic Amyloidosis
Condition: Multiple Myeloma and Plasma Cell Neoplasm
Interventions: Biological: filgrastim;   Drug: bortezomib;   Drug: melphalan;   Procedure: autologous hematopoietic stem cell transplantation
29 Unknown † Human Immune Globulin in Treating Patients With Primary Amyloidosis That is Causing Heart Dysfunction
Condition: Multiple Myeloma and Plasma Cell Neoplasm
Interventions: Biological: therapeutic immune globulin;   Other: laboratory biomarker analysis
30 Active, not recruiting A Pilot Study of Lenalidomide, Melphalan and Dexamethasone in AL Amyloidosis
Conditions: Leukemia;   Amyloidosis
Interventions: Drug: Lenalidomide;   Drug: Melphalan;   Drug: Dexamethasone
31 Recruiting Trial of Two Stem Cell Doses To Reduce Transplant Induced Symptom Burden
Conditions: Multiple Myeloma;   Primary Amyloidosis
Interventions: Drug: Melphalan;   Procedure: Stem Cell Infusion;   Behavioral: Questionnaires;   Drug: Granulocyte-colony stimulating factor (G-CSF);   Procedure: Apheresis
32 Completed Cyclophosphamide, Lenalidomide and Dexamethasone (CLD) for Previously Treated Patients With AL Amyloidosis
Condition: Amyloidosis
Interventions: Drug: cyclophosphamide;   Drug: lenalidomide;   Drug: dexamethasone
33 Recruiting Bortezomib/Dexamethasone (BD), Followed By Autologous Stem Cell Transplantation and Maintenance Bortezomib/Dexamethasone For the Initial Treatment of Monoclonal Immunoglobulin Deposition Disease (MIDD) Associated With Multiple Myeloma and AL Amyloidosis
Conditions: Light Chain Deposition Disease (LCDD or MIDD);   Light Chain and Heavy Chain Deposition Disease (LHCDD or MIDD);   Monoclonal Immunoglobulin Deposition Disease (MIDD);   Amyloidosis
Intervention: Drug: Bortezomib/Dexamethasone (BD), Followed By Autologous STC & Maintenance Bortezomib/Dexamethasone
34 Active, not recruiting Bortezomib, Melphalan, and Dexamethasone in Treating Patients With Primary Amyloidosis or Light Chain Deposition Disease
Condition: Multiple Myeloma and Plasma Cell Neoplasm
Interventions: Drug: bortezomib;   Drug: dexamethasone;   Drug: melphalan;   Genetic: microarray analysis;   Other: flow cytometry;   Other: laboratory biomarker analysis;   Procedure: quality-of-life assessment
35 Completed
Has Results 		Lenalidomide, Cyclophosphamide, and Dexamethasone in Treating Patients With Primary Systemic Amyloidosis
Condition: Multiple Myeloma and Plasma Cell Neoplasm
Interventions: Drug: cyclophosphamide;   Drug: dexamethasone;   Drug: lenalidomide
36 Completed Melphalan, Thalidomide, and Dexamethasone in Treating Patients With Newly Diagnosed, Previously Untreated Primary Systemic Amyloidosis
Condition: Multiple Myeloma and Plasma Cell Neoplasm
Interventions: Biological: filgrastim;   Drug: dexamethasone;   Drug: melphalan;   Drug: thalidomide
37 Completed High-Dose Melphalan Plus Peripheral Stem Cell Transplantation in Treating Patients With Primary Systemic Amyloidosis
Condition: Multiple Myeloma and Plasma Cell Neoplasm
Interventions: Biological: filgrastim;   Drug: melphalan;   Procedure: bone marrow ablation with stem cell support;   Procedure: peripheral blood stem cell transplantation
38 Completed Chemotherapy Plus Peripheral Stem Cell Transplant in Treating Patients Who Have Multiple Myeloma or Primary Systemic Amyloidosis
Condition: Multiple Myeloma and Plasma Cell Neoplasm
Interventions: Biological: filgrastim;   Biological: recombinant interferon alfa;   Biological: sargramostim;   Drug: busulfan;   Drug: cyclophosphamide;   Drug: melphalan;   Procedure: autologous bone marrow transplantation;   Procedure: bone marrow ablation with stem cell support;   Procedure: peripheral blood stem cell transplantation
39 Completed 4'-Iodo-4'-Deoxydoxorubicin in Treating Patients With Primary Systemic Amyloidosis
Condition: Multiple Myeloma and Plasma Cell Neoplasm
Intervention: Drug: 4'-iodo-4'-deoxydoxorubicin
40 Terminated Amifostine and Melphalan in Treating Patients With Primary Systemic Amyloidosis Who Are Undergoing Peripheral Stem Cell Transplantation
Conditions: Drug/Agent Toxicity by Tissue/Organ;   Multiple Myeloma and Plasma Cell Neoplasm
Interventions: Biological: filgrastim;   Drug: amifostine trihydrate;   Drug: melphalan;   Procedure: bone marrow ablation with stem cell support;   Procedure: peripheral blood stem cell transplantation
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† Indicates status has not been verified in more than two years