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| Sponsor: | Massachusetts General Hospital |
|---|---|
| Collaborators: |
CURE Foundation The Commonwealth Fund National Alliance for Autism Research Nancy Lurie Marks Family Foundation |
| Information provided by: | Massachusetts General Hospital |
| ClinicalTrials.gov Identifier: | NCT00319722 |
Purpose
This study uses EEG to study brain waves at rest and in response to specific auditory and visual sensory stimuli in autistic children. We hypothesize that, compared to same age peers, autistics will show abnormalities in their electrophysiologic processing of sounds (tones and phonemes)and visual stimuli (flashes of light)and that these abnormalities will be able to separate autistics not only from typical children but also into clinical subgroups with specific biological/electrophysiological characteristics. We hope to find biological measures which will prove diagnostic of autism in very young children and which can be used in the measurement of treatment outcome in future intervention trials.
| Study Type: | Observational |
| Study Design: | Observational Model: Case Control Time Perspective: Prospective |
| Official Title: | Electrophysiologic Indicators of Gating and Timing Abnormalities in Autism |
| Estimated Enrollment: | 130 |
| Study Start Date: | February 2006 |
| Estimated Study Completion Date: | March 2011 |
| Estimated Primary Completion Date: | March 2011 (Final data collection date for primary outcome measure) |
Show Detailed Description Eligibility| Ages Eligible for Study: | 3 Months to 8 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Non-Probability Sample |
autistic children meeting criteria for autism based on ADOS and ADI and clinical DSM IV or their siblings between the ages of 3 months to 13 years.
Inclusion Criteria:
autistic children or their younger siblings between the ages of 3 months to 8 year
Controls: typically developing children 3mo to 8 years without known language or social disorder and not related to child with autism
Exclusion Criteria: progressive encephalopathy, treatment with multiple antiepileptic drugs, known genetic diagnosis.
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Contacts and Locations| Contact: Alyssa Orinstein | 617-966-9766 | transcend@partners.org |
| United States, Massachusetts | |
| MGH LADDERS Clinic | Recruiting |
| Lexington, Massachusetts, United States, 02421 | |
| Contact: Katherine M. Martien, M.D. 781-860-1720 kmartien@partners.org | |
| Principal Investigator: Katherine M. Martien, M.D. | |
| Principal Investigator: | Katherine M. Martien, M.D. | Massachusetts General Hospital |
| Principal Investigator: | Martha Herbert, M.D. | Massachusetts General Hospital |
More Information
| Responsible Party: | Katherine M. Martien, M.D., Principal Investigator, Massachusetts General Hospital |
| ClinicalTrials.gov Identifier: | NCT00319722 History of Changes |
| Other Study ID Numbers: | 2005-P-000868/3 |
| Study First Received: | April 27, 2006 |
| Last Updated: | May 3, 2010 |
| Health Authority: | United States: Institutional Review Board |
|
autism pervasive developmental disorder evoked potentials EEG Coherence |
|
Autistic Disorder Child Development Disorders, Pervasive Mental Disorders Diagnosed in Childhood Mental Disorders |
